.viz-container[data-astro-cid-yh6d3tea]{display:flex;justify-content:center;margin:1.5rem 0}conditional-prob-explorer[data-astro-cid-yh6d3tea]{display:flex;flex-direction:column;align-items:center;gap:1rem;width:100%;max-width:420px}#cpe-svg[data-astro-cid-yh6d3tea]{display:block;margin:0 auto}.cpe-controls[data-astro-cid-yh6d3tea]{display:flex;flex-direction:column;gap:.6rem;width:100%}.cpe-slider-row[data-astro-cid-yh6d3tea]{display:grid;grid-template-columns:7rem 1fr;align-items:center;gap:.5rem}.cpe-slider-row[data-astro-cid-yh6d3tea] label[data-astro-cid-yh6d3tea]{font-size:.9rem;font-weight:600;color:var(--text-primary);white-space:nowrap}.cpe-slider-row[data-astro-cid-yh6d3tea] input[data-astro-cid-yh6d3tea][type=range]{width:100%;accent-color:var(--viz-1);cursor:pointer}#cpe-toggle[data-astro-cid-yh6d3tea]{align-self:center;margin-top:.4rem;padding:.45rem 1.2rem;border:2px solid var(--viz-2);border-radius:6px;background:transparent;color:var(--viz-2);font-weight:600;font-size:.9rem;cursor:pointer;transition:background .15s,color .15s}#cpe-toggle[data-astro-cid-yh6d3tea]:hover,#cpe-toggle[data-astro-cid-yh6d3tea]:focus-visible{background:var(--viz-2);color:#fff;outline:none}conditional-prob-explorer[data-astro-cid-yh6d3tea][data-conditional=true] #cpe-toggle[data-astro-cid-yh6d3tea]{background:var(--viz-2);color:#fff}.cpe-formula-panel[data-astro-cid-yh6d3tea]{width:100%;font-size:.875rem;display:flex;flex-direction:column;gap:.4rem}.cpe-unconditional[data-astro-cid-yh6d3tea]{display:flex;flex-wrap:wrap;gap:.75rem 1.25rem;color:var(--text-primary);padding:.5rem .75rem;background:var(--surface-2, var(--bg-secondary, #f5f5f5));border-radius:6px}.cpe-conditional[data-astro-cid-yh6d3tea]{padding:.5rem .75rem;border-radius:6px;border-left:3px solid var(--viz-3);background:var(--surface-2, var(--bg-secondary, #f5f5f5));color:var(--text-primary);transition:background 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var(--color-light-gray);border-radius:8px;padding:1.25rem}.tcz-table[data-astro-cid-eweqq2ws]{width:100%;border-collapse:collapse;font-size:.9rem}.tcz-table[data-astro-cid-eweqq2ws] th[data-astro-cid-eweqq2ws],.tcz-table[data-astro-cid-eweqq2ws] td[data-astro-cid-eweqq2ws]{border:1px solid var(--color-light-gray);padding:.5rem .75rem;text-align:center}.tcz-table[data-astro-cid-eweqq2ws] th[data-astro-cid-eweqq2ws]{background:var(--bg-surface-alt);font-weight:700;font-size:.85rem}.tcz-col-sub[data-astro-cid-eweqq2ws],.tcz-row-sub[data-astro-cid-eweqq2ws]{font-weight:400;font-size:.75rem;color:var(--text-secondary)}.tcz-row-label[data-astro-cid-eweqq2ws]{text-align:left;font-weight:600;white-space:nowrap;font-size:.85rem}.tcz-row-label-total[data-astro-cid-eweqq2ws]{font-weight:400;color:var(--text-secondary)}.tcz-cell-marginal[data-astro-cid-eweqq2ws]{background:var(--bg-surface-alt);font-weight:600;color:var(--text-secondary)}.tcz-cell-n[data-astro-cid-eweqq2ws]{background:var(--bg-surface-alt);font-weight:700}.tcz-cell-ab[data-astro-cid-eweqq2ws]{font-weight:700;color:var(--viz-3);background:color-mix(in srgb,var(--viz-3) 10%,transparent)}.tcz-row-b[data-astro-cid-eweqq2ws] td[data-astro-cid-eweqq2ws]{transition:background .3s}table-condition-zoom[data-astro-cid-eweqq2ws][data-conditional=true] .tcz-row-b[data-astro-cid-eweqq2ws] td[data-astro-cid-eweqq2ws]{background:color-mix(in srgb,var(--viz-2) 8%,transparent)}.tcz-row-bprime[data-astro-cid-eweqq2ws],.tcz-row-totals[data-astro-cid-eweqq2ws]{transition:opacity .35s ease,max-height .35s ease;overflow:hidden}.tcz-row-bprime[data-astro-cid-eweqq2ws] td[data-astro-cid-eweqq2ws],.tcz-row-totals[data-astro-cid-eweqq2ws] td[data-astro-cid-eweqq2ws]{transition:padding .35s ease,font-size .35s ease,opacity .35s ease}.tcz-row-bprime[data-astro-cid-eweqq2ws].tcz-collapsed td[data-astro-cid-eweqq2ws],.tcz-row-totals[data-astro-cid-eweqq2ws].tcz-collapsed td[data-astro-cid-eweqq2ws]{padding-top:0;padding-bottom:0;font-size:0;opacity:0;border-top-width:0;border-bottom-width:0}.tcz-cell-b-total[data-astro-cid-eweqq2ws]{transition:background .3s,color .3s}.tcz-cell-b-total[data-astro-cid-eweqq2ws].tcz-denom-active{background:color-mix(in srgb,var(--viz-2) 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.tcz-den[data-astro-cid-eweqq2ws]{color:var(--viz-2);font-weight:600}.tcz-result[data-astro-cid-eweqq2ws]{font-weight:700;color:var(--text-primary);font-size:.9rem;transition:color .3s}table-condition-zoom[data-astro-cid-eweqq2ws][data-conditional=true] .tcz-result[data-astro-cid-eweqq2ws]{color:var(--color-success)}.tcz-formula-text[data-astro-cid-eweqq2ws]{font-size:.82rem;color:var(--text-secondary);margin:0;line-height:1.4}.tcz-controls[data-astro-cid-eweqq2ws]{display:flex;align-items:center;gap:1rem;flex-wrap:wrap}#tcz-toggle[data-astro-cid-eweqq2ws]{padding:.45rem 1.1rem;border:2px solid var(--viz-2);border-radius:6px;background:transparent;color:var(--viz-2);font-weight:600;font-size:.88rem;cursor:pointer;transition:background .15s,color .15s;white-space:nowrap}#tcz-toggle[data-astro-cid-eweqq2ws]:hover,#tcz-toggle[data-astro-cid-eweqq2ws]:focus-visible{background:var(--viz-2);color:#fff;outline:none}table-condition-zoom[data-astro-cid-eweqq2ws][data-conditional=true] #tcz-toggle[data-astro-cid-eweqq2ws]{background:var(--viz-2);color:#fff}.tcz-hint[data-astro-cid-eweqq2ws]{font-size:.8rem;color:var(--text-muted);font-style:italic}.viz-container[data-astro-cid-6bdxg47r]{display:flex;justify-content:center;margin:1.5rem 0}tree-diagram-builder[data-astro-cid-6bdxg47r]{display:block;width:100%;max-width:700px}.tdb-wrapper[data-astro-cid-6bdxg47r]{border:1px solid var(--color-light-gray);border-radius:8px;background:var(--bg-surface);padding:1.25rem;display:flex;flex-direction:column;gap:1rem}.tdb-header[data-astro-cid-6bdxg47r]{display:flex;justify-content:space-between;align-items:flex-start;gap:1rem;flex-wrap:wrap}.tdb-instructions[data-astro-cid-6bdxg47r]{margin:0;font-size:.85rem;color:var(--text-secondary);flex:1;line-height:1.4}.tdb-btn-row[data-astro-cid-6bdxg47r]{display:flex;gap:.5rem;flex-shrink:0}.tdb-btn-row[data-astro-cid-6bdxg47r] button[data-astro-cid-6bdxg47r]{padding:.35rem 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.15s}.tdb-input[data-astro-cid-6bdxg47r]:focus{outline:none;border-color:var(--viz-2)}.tdb-input[data-astro-cid-6bdxg47r]::-webkit-inner-spin-button,.tdb-input[data-astro-cid-6bdxg47r]::-webkit-outer-spin-button{-webkit-appearance:none}.tdb-input[data-astro-cid-6bdxg47r][type=number]{-moz-appearance:textfield}.tdb-sum-row[data-astro-cid-6bdxg47r]{position:relative;z-index:1;margin-top:3px;font-size:.7rem;white-space:nowrap;color:var(--text-muted)}.tdb-sum-indicator[data-astro-cid-6bdxg47r]{font-weight:600}.tdb-sum-ok[data-astro-cid-6bdxg47r]{color:var(--color-success)}.tdb-sum-error[data-astro-cid-6bdxg47r]{color:var(--color-danger)}.tdb-sum-neutral[data-astro-cid-6bdxg47r]{color:var(--text-muted)}.tdb-sum-warn[data-astro-cid-6bdxg47r]{color:var(--color-warning)}.tdb-leaf[data-astro-cid-6bdxg47r]{display:flex;flex-direction:column;align-items:flex-start;padding-left:.5rem;gap:.15rem}.tdb-leaf-label[data-astro-cid-6bdxg47r]{font-size:.78rem;font-weight:600;color:var(--text-secondary)}.tdb-val-missing[data-astro-cid-6bdxg47r]{font-size:.88rem;font-weight:700;color:var(--text-muted)}.tdb-val-present[data-astro-cid-6bdxg47r]{font-size:.95rem;font-weight:700;color:var(--viz-3)}.tdb-total-sum[data-astro-cid-6bdxg47r]{padding:.5rem 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var(--color-light-gray);border-radius:8px;background:var(--bg-surface);padding:1.25rem}.it-sliders[data-astro-cid-js2ctvrm]{display:flex;flex-direction:column;gap:.5rem}.it-slider-row[data-astro-cid-js2ctvrm]{display:grid;grid-template-columns:8rem 1fr;align-items:center;gap:.5rem}.it-slider-row[data-astro-cid-js2ctvrm] label[data-astro-cid-js2ctvrm]{font-size:.84rem;font-weight:600;color:var(--text-primary)}.it-slider-row[data-astro-cid-js2ctvrm] input[data-astro-cid-js2ctvrm][type=range]{width:100%;accent-color:var(--viz-3);cursor:pointer}.it-derived[data-astro-cid-js2ctvrm]{font-size:.82rem;color:var(--text-secondary);padding-left:.25rem;margin-top:.1rem}.it-badge[data-astro-cid-js2ctvrm]{padding:.5rem .75rem;border-radius:6px;font-size:.84rem;font-weight:600;line-height:1.4}.it-badge-independent[data-astro-cid-js2ctvrm]{background:var(--color-success-light);border:1px solid var(--color-success-border);color:color-mix(in srgb,var(--color-success) 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0}rare-disease-flow[data-astro-cid-vzo7cqzp]{display:block;width:100%;max-width:780px}.rdf-layout[data-astro-cid-vzo7cqzp]{display:flex;gap:1.5rem;align-items:flex-start;flex-wrap:wrap}.rdf-grid-col[data-astro-cid-vzo7cqzp]{display:flex;flex-direction:column;align-items:center;gap:.75rem;flex-shrink:0}#rdf-svg[data-astro-cid-vzo7cqzp]{display:block;border:1px solid var(--color-light-gray);border-radius:6px;background:var(--bg-surface)}.rdf-legend[data-astro-cid-vzo7cqzp]{display:flex;flex-direction:column;gap:.3rem;font-size:.78rem;color:var(--text-secondary)}.rdf-legend-item[data-astro-cid-vzo7cqzp]{display:flex;align-items:center;gap:.4rem}.rdf-legend-fn[data-astro-cid-vzo7cqzp],.rdf-legend-tn[data-astro-cid-vzo7cqzp]{opacity:.6}.rdf-swatch[data-astro-cid-vzo7cqzp]{display:inline-block;width:12px;height:12px;border-radius:50%;flex-shrink:0}.rdf-swatch-tp[data-astro-cid-vzo7cqzp]{background:var(--viz-1)}.rdf-swatch-fn[data-astro-cid-vzo7cqzp]{background:var(--viz-1);opacity:.38}.rdf-swatch-fp[data-astro-cid-vzo7cqzp]{background:var(--viz-2)}.rdf-swatch-tn[data-astro-cid-vzo7cqzp]{background:var(--text-muted);opacity:.4}.rdf-controls-col[data-astro-cid-vzo7cqzp]{display:flex;flex-direction:column;gap:1rem;flex:1;min-width:240px}.rdf-sliders[data-astro-cid-vzo7cqzp]{display:flex;flex-direction:column;gap:.55rem}.rdf-slider-row[data-astro-cid-vzo7cqzp]{display:flex;flex-direction:column;gap:.2rem}.rdf-slider-row[data-astro-cid-vzo7cqzp] label[data-astro-cid-vzo7cqzp]{font-size:.82rem;font-weight:600;color:var(--text-primary)}.rdf-slider-row[data-astro-cid-vzo7cqzp] input[data-astro-cid-vzo7cqzp][type=range]{width:100%;accent-color:var(--viz-1);cursor:pointer}#rdf-toggle[data-astro-cid-vzo7cqzp]{align-self:flex-start;padding:.45rem 1.1rem;border:2px solid var(--viz-1);border-radius:6px;background:transparent;color:var(--viz-1);font-weight:600;font-size:.88rem;cursor:pointer;transition:background .15s,color .15s}#rdf-toggle[data-astro-cid-vzo7cqzp]:hover,#rdf-toggle[data-astro-cid-vzo7cqzp]:focus-visible{background:var(--viz-1);color:#fff;outline:none}rare-disease-flow[data-astro-cid-vzo7cqzp][data-conditional=true] #rdf-toggle[data-astro-cid-vzo7cqzp]{background:var(--viz-1);color:#fff}.rdf-formula[data-astro-cid-vzo7cqzp]{display:flex;flex-direction:column;gap:.3rem;font-size:.84rem;background:var(--bg-surface-alt);border-radius:6px;padding:.75rem}.rdf-formula-row[data-astro-cid-vzo7cqzp]{display:flex;align-items:baseline;gap:.4rem}.rdf-label[data-astro-cid-vzo7cqzp]{flex:1;color:var(--text-secondary)}.rdf-label-small[data-astro-cid-vzo7cqzp]{font-size:.78rem;flex:unset}.rdf-label-result[data-astro-cid-vzo7cqzp]{font-weight:700;color:var(--text-primary)}.rdf-eq[data-astro-cid-vzo7cqzp]{color:var(--text-muted)}.rdf-val[data-astro-cid-vzo7cqzp]{font-weight:600;color:var(--text-primary);min-width:3.5rem;text-align:right}.rdf-formula-divider[data-astro-cid-vzo7cqzp]{border-top:1px solid var(--color-light-gray);margin:.25rem 0}.rdf-formula-row-counts[data-astro-cid-vzo7cqzp]{font-size:.78rem}.rdf-count-tp[data-astro-cid-vzo7cqzp]{color:var(--viz-1);font-weight:700}.rdf-count-fp[data-astro-cid-vzo7cqzp]{color:var(--viz-2);font-weight:700}.rdf-formula-highlight[data-astro-cid-vzo7cqzp]{margin-top:.15rem;padding-top:.35rem;border-top:2px solid var(--color-light-gray)}.rdf-result-value[data-astro-cid-vzo7cqzp]{font-size:1.15rem;font-weight:700;min-width:3.5rem;text-align:right}.rdf-result-low[data-astro-cid-vzo7cqzp]{color:var(--viz-1)}.rdf-result-high[data-astro-cid-vzo7cqzp]{color:var(--color-success)}.rdf-badge[data-astro-cid-vzo7cqzp]{padding:.45rem .75rem;border-radius:6px;font-size:.82rem;font-weight:600;line-height:1.35}.rdf-badge-surprise[data-astro-cid-vzo7cqzp]{background:color-mix(in srgb,var(--viz-1) 12%,transparent);color:color-mix(in srgb,var(--viz-1) 80%,var(--color-dark));border:1px solid color-mix(in srgb,var(--viz-1) 35%,transparent)}.rdf-badge-neutral[data-astro-cid-vzo7cqzp]{background:var(--bg-surface-alt);color:var(--text-secondary);border:1px solid var(--color-light-gray)}